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LEFTY2

Gene

left-right determination factor 2

HGNCHGNC:3122EnsemblENSG00000143768NCBI Gene7044
Locus: gene with protein productLocation: 1q42.12

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTGFB4 · EBAF · LEFTA · LEFTYA
View full nomenclature history (6)
Previous symbolsTGFB4, EBAF
Alias symbolsLEFTA, LEFTYA
Previous namesendometrial bleeding associated factor (left-right determination, factor A; transforming growth factor beta superfamily)
Alias namestransforming growth factor, beta-4 (endometrial bleeding-associated factor; LEFTY A)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Heterotaxia
Visceral heterotaxy
Kartagener Syndrome
Atrial septal defect
Small Cell Lung Carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Transforming growth factor beta superfamily

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.