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LGR5

Gene

leucine rich repeat containing G protein-coupled receptor 5

HGNCHGNC:4504EnsemblENSG00000139292NCBI Gene8549
Locus: gene with protein productLocation: 12q21.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGPR67 · GPR49 · HG38 · FEX
View full nomenclature history (5)
Previous symbolsGPR67, GPR49
Alias symbolsHG38, FEX
Previous namesG protein-coupled receptor 49

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Gastrointestinal Diseases
Acne Vulgaris
Carcinoid syndrome
Adverse effect

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

G protein-coupled receptors, Class A orphans

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.