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LIG3

Gene

DNA ligase 3

HGNCHGNC:6600EnsemblENSG00000005156NCBI Gene3980
Locus: gene with protein productLocation: 17q12

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asLIG2 · LIG3alpha
View full nomenclature history (5)
Previous symbolsLIG2
Alias symbolsLIG3alpha
Previous namesligase II, DNA, ATP-dependent, ligase III, DNA, ATP-dependent
Alias namesDNA ligase III

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Cerebellar Ataxia
Macular Degeneration
Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Zinc fingers PARP-typeDNA ligases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-08-01.
Open TargetsGene–disease associations from the Open Targets Platform.