LRP1

Gene

LDL receptor related protein 1

HGNCHGNC:6692 EnsemblENSG00000123384 NCBI Gene4035

Locus: gene with protein productLocation: 12q13.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Prolow-density lipoprotein receptor-related protein 1Q07954

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asAPR · A2MR · LRP · CD91 · LRP1A · APOER · IGFBP3R1 · IGFBP-3R

View full nomenclature history (11)

Previous symbolsAPR, A2MR

Alias symbolsLRP, CD91, LRP1A, APOER, IGFBP3R1, IGFBP-3R

Previous namesalpha-2-macroglobulin receptor, low density lipoprotein receptor-related protein 1

Alias namestransforming growth factor-β receptor type V

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Alzheimer's Disease

Parkinson's Disease

Multiple Sclerosis

Lysosomal Storage Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesLow density lipoprotein receptorsMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.