LRRK2

Gene

leucine rich repeat kinase 2

HGNCHGNC:18618 EnsemblENSG00000188906 NCBI Gene120892

Locus: gene with protein productLocation: 12q12

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Leucine-rich repeat serine/threonine-protein kinase 2Q5S007

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPARK8 · ROCO2 · DKFZp434H2111 · FLJ45829 · RIPK7

View full nomenclature history (7)

Previous symbolsPARK8

Alias symbolsROCO2, DKFZp434H2111, FLJ45829, RIPK7

Previous namesParkinson disease (autosomal dominant) 8

Alias namesdardarin

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Parkinson's Disease

Neurodegenerative Diseases

Genetic Diseases, Inborn

Alzheimer's Disease

Placental abruption

Multiple Sclerosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

ROCO familyArmadillo like helical domain containingLeucine rich repeat kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.