MAN1B1

Gene

mannosidase alpha class 1B member 1

HGNCHGNC:6823 EnsemblENSG00000177239 NCBI Gene11253

Locus: gene with protein productLocation: 9q34.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMANA-ER · MRT15 · ERManI · ERMan1

View full nomenclature history (11)

Alias symbolsMANA-ER, MRT15, ERManI, ERMan1

Previous namesmannosidase, alpha, class 1B, member 1

Alias namesendoplasmic reticulum alpha-mannosidase 1, alpha 1,2-mannosidase, endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1, ER alpha 1,2-mannosidase, Man9GlcNAc2-specific processing alpha-mannosidase, endoplasmic Reticulum Class I alpha-mannosidase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Autosomal recessive non-syndromic intellectual disability

Genetic Diseases, Inborn

COVID-19

Neurodegenerative Diseases

Carcinoma, Hepatocellular

Urinary bladder carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Mannosidases alpha class 1

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.