MAP2K4

Gene

mitogen-activated protein kinase kinase 4

HGNCHGNC:6844 EnsemblENSG00000065559 NCBI Gene6416

Locus: gene with protein productLocation: 17p12

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSERK1 · MEK4 · JNKK1 · PRKMK4 · MKK4 · MAPKK4 · SAPKK1 · SKK1 · JNKK · SEK1

View full nomenclature history (13)

Previous symbolsSERK1

Alias symbolsMEK4, JNKK1, PRKMK4, MKK4, MAPKK4, SAPKK1, SKK1, JNKK, SEK1

Previous namesSAPK/ERK kinase 1

Alias namesstress-activated protein kinase kinase 1, c-Jun NH2-terminal kinase kinase 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Breast adenocarcinoma

Lysosomal Storage Diseases

Pancreatic adenocarcinoma

Colorectal adenocarcinoma

Carcinoma, Pancreatic Ductal

Lymphoid neoplasm

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Mitogen-activated protein kinase kinasesMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-08-02.

Open TargetsGene–disease associations from the Open Targets Platform.