MAP3K4

Gene

mitogen-activated protein kinase kinase kinase 4

HGNCHGNC:6856 EnsemblENSG00000085511 NCBI Gene4216

Locus: gene with protein productLocation: 6q26

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMEKK4 · MTK1 · MAPKKK4 · KIAA0213

View full nomenclature history (4)

Previous symbolsMEKK4

Alias symbolsMTK1, MAPKKK4, KIAA0213

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Aortic Valve Stenosis

Myocardial Infarction

Smoking initiation

Coronary Artery Disease

Heart Diseases

Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Mitogen-activated protein kinase kinase kinases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.