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MAP4K5

Gene

mitogen-activated protein kinase kinase kinase kinase 5

HGNCHGNC:6867EnsemblENSG00000012983NCBI Gene11183
Locus: gene with protein productLocation: 14q22.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKHS1 · GCKR · KHS
View full nomenclature history (5)
Alias symbolsKHS1, GCKR, KHS
Alias nameskinase homologous to SPS1/STE20, germinal center kinase-related

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Dupuytren Contracture
Neurodegenerative Diseases
Hypertension
Genetic Diseases, Inborn
Cardiovascular Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

MAP4K family (GCK-I subfamily)

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-02-16.
Open TargetsGene–disease associations from the Open Targets Platform.