Disease

Dupuytren Contracture

Late-stage therapeutic development

Also known as Dupuytren's Contracture, Dupuytren's Disease.

Clinical trials

Associated genes

Related proteins

Current focus

Matrix metalloproteinase-14 biologyTenascin biologyTherapeutic development

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low

Key developments

1 clinical trial expected to report results, the earliest in Q3 2027.

Upcoming Milestones

Q3 2027A Phase 1/2, Multicenter, Dose Escalating, Dose Expanding, Adaptive Study to Assess Safety, Tolerability, Efficacy and Pharmacokinetics of Collagenase CNT201 in Adult Participants With Dupuytren's Contracture

Major developments

Upcoming trial readoutImportant

A Phase 1/2, Multicenter, Dose Escalating, Dose Expanding, Adaptive Study to Assess Safety, Tolerability, Efficacy and Pharmacokinetics of Collagenase CNT201 in Adult Participants With Dupuytren's Contracture

Results expected Q3 20272026-06-12

Major clinical milestoneImportant

DupuytrEn Treatment EffeCtiveness Trial (DETECT): Needle Fasciotomy, Surgery or Collagenase Injection for Dupuytren's Contracture

Primary completion2026-05-31

Clinical Milestones3View

Results expected 1

2026-06-12A Phase 1/2, Multicenter, Dose Escalating, Dose Expanding, Adaptive Study to Assess Safety, Tolerability, Efficacy and Pharmacokinetics of Collagenase CNT201 in Adult Participants With Dupuytren's ContractureResults expected Q3 2027

Recently completed 2

2026-05-31DupuytrEn Treatment EffeCtiveness Trial (DETECT): Needle Fasciotomy, Surgery or Collagenase Injection for Dupuytren's ContracturePrimary completion
2025-12-01Percutaneous Needle Fasciotomy (PNF) +/- Corticosteroid Injection for Dupuytren's Contracture (DC) Affecting Metacarpophalangeal Joints (MCP) . A Randomized Controlled TrialPrimary completion

Activity timeline3

2026-06-12ClinicalA Phase 1/2, Multicenter, Dose Escalating, Dose Expanding, Adaptive Study to Assess Safety, Tolerability, Efficacy and Pharmacokinetics of Collagenase CNT201 in Adult Participants With Dupuytren's ContractureResults expected Q3 2027
2026-05-31ClinicalDupuytrEn Treatment EffeCtiveness Trial (DETECT): Needle Fasciotomy, Surgery or Collagenase Injection for Dupuytren's ContracturePrimary completion
2025-12-01ClinicalPercutaneous Needle Fasciotomy (PNF) +/- Corticosteroid Injection for Dupuytren's Contracture (DC) Affecting Metacarpophalangeal Joints (MCP) . A Randomized Controlled TrialPrimary completion

Clinical trials

8 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme

All trials

Active

Late-stage

Completed

Late-stage studies

DupuytrEn Treatment EffeCtiveness Trial (DETECT): Needle Fasciotomy, Surgery or Collagenase Injection for Dupuytren's Contracture

Phase 4 · Active, not recruiting · Tampere University

Percutaneous Needle Fasciotomy (PNF) +/- Corticosteroid Injection for Dupuytren's Contracture (DC) Affecting Metacarpophalangeal Joints (MCP) . A Randomized Controlled Trial

Phase 4 · Recruiting · Regionshospitalet Silkeborg

The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery: a Prospective, Randomized, Blinded Controlled Trial

Phase 4 · Active, not recruiting · St. Luke's Hospital, Pennsylvania

Clinical Effectiveness of Splinting After Collagenase Clostridium Histolyticum Injection for Dupuytren Contracture

Phase 3 · Completed · Foundation for Orthopaedic Research and Education

A Randomized Controlled Trial (RCT) Comparing Clostridium Histolyticum With Needle Aponeurotomy.

Phase 4 · Completed · University Hospital, Akershus

Collagenase and Needle Aponeurotomy: Single Modality Versus Combination Treatment for Dupuytren's Disease

Phase 3 · Withdrawn · University of Alberta

Recruiting

Percutaneous Needle Fasciotomy (PNF) +/- Corticosteroid Injection for Dupuytren's Contracture (DC) Affecting Metacarpophalangeal Joints (MCP) . A Randomized Controlled Trial

Phase 4 · Recruiting · Regionshospitalet Silkeborg

Phase 1/2 · Recruiting · CONNEXT

Recently completed

Clinical Effectiveness of Splinting After Collagenase Clostridium Histolyticum Injection for Dupuytren Contracture

Phase 3 · Completed · Foundation for Orthopaedic Research and Education

A Randomized Controlled Trial (RCT) Comparing Clostridium Histolyticum With Needle Aponeurotomy.

Phase 4 · Completed · University Hospital, Akershus

A Randomized Trial Comparing Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Outpatient Soft Tissue Hand Surgery

Phase 2 · Completed · University of Southern California

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

COL15A10.59 MAFB0.52 EBF20.50 WNT7B0.48 SDK10.46 PJA20.45 TNC0.44 NEDD40.43 ITGA110.43 EPDR10.43 MAP4K50.43 DDR20.42

Disease biology

4 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Tenascinvia TNC0.44 Discoidin domain-containing receptor 2via DDR20.42 Matrix metalloproteinase-14via MMP140.39 Leukemia inhibitory factorvia LIF0.27

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A fibromatosis of the palmar fascia characterized by thickening and contracture of the fibrous bands on the palmar surfaces of the hand and fingers. It arises most commonly in men between the ages of 30 and 50.

Synonyms

Dupuytren's Contracture, Dupuytren's Disease

References & data sources

Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
Related entities are derived from literature co-mention (studied together) — associative, not causal.