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NEDD4

Gene

NEDD4 E3 ubiquitin protein ligase

HGNCHGNC:7727EnsemblENSG00000069869NCBI Gene4734
Locus: gene with protein productLocation: 15q21.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKIAA0093 · MGC176705 · NEDD4-1 · RPF1
View full nomenclature history (7)
Alias symbolsKIAA0093, MGC176705, NEDD4-1, RPF1
Previous namesneural precursor cell expressed, developmentally down-regulated 4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Alias namesreceptor-potentiating factor 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Keloid
Dupuytren Contracture
Neurodegenerative Diseases
Hypertension

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Nedd4 family E3 ubiquitin protein ligases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.