MAPK11

Gene

mitogen-activated protein kinase 11

HGNCHGNC:6873 EnsemblENSG00000185386 NCBI Gene5600

Locus: gene with protein productLocation: 22q13.33

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Mitogen-activated protein kinase 11Q15759

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPRKM11 · p38-2 · p38Beta · SAPK2

View full nomenclature history (4)

Previous symbolsPRKM11

Alias symbolsp38-2, p38Beta, SAPK2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Colorectal Neoplasms

Neoplasms

Carcinoma, Hepatocellular

Gastrointestinal Stromal Tumors

Facioscapulohumeral muscular dystrophy

Esophageal Neoplasms

COVID-19

Liver Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Mitogen-activated protein kinase 11-14 (p38) family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.