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MAPK3

Gene

mitogen-activated protein kinase 3

HGNCHGNC:6877EnsemblENSG00000102882NCBI Gene5595
Locus: gene with protein productLocation: 16p11.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPRKM3 · ERK1 · p44mapk · p44erk1 · ERK-1
View full nomenclature history (5)
Previous symbolsPRKM3
Alias symbolsERK1, p44mapk, p44erk1, ERK-1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplasms
Noonan syndrome
Cardiomyopathy, Hypertrophic
Costello syndrome
Carcinoma, Non-Small-Cell Lung
Tuberculosis
Cardiofaciocutaneous syndrome
Autoimmune disorder of central nervous system
Obesity disorder

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Mitogen-activated protein kinase 3 and 1 (ERK1/2) family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-03-17.
Open TargetsGene–disease associations from the Open Targets Platform.