MDM2

Gene

MDM2 proto-oncogene

HGNCHGNC:6973 EnsemblENSG00000135679 NCBI Gene4193

Locus: gene with protein productLocation: 12q15

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHDM2 · MGC5370

View full nomenclature history (6)

Alias symbolsHDM2, MGC5370

Previous namesmouse double minute 2, human homolog of; p53-binding protein, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse), Mdm2 p53 binding protein homolog (mouse), MDM2 proto-oncogene, E3 ubiquitin protein ligase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Ductal, Breast

Hemangioblastoma

Skin squamous cell carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ring finger proteinsZinc fingers RANBP2-type

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.