MET

Gene

MET proto-oncogene, receptor tyrosine kinase

HGNCHGNC:7029 EnsemblENSG00000105976 NCBI Gene4233

Locus: gene with protein productLocation: 7q31.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Hepatocyte growth factor receptorP08581

Protein · therapeutic target

Clinically validated target · 8 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHGFR · RCCP2 · DFNB97

View full nomenclature history (5)

Alias symbolsHGFR, RCCP2, DFNB97

Previous namesmet proto-oncogene

Alias nameshepatocyte growth factor receptor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Renal Cell

Hereditary papillary renal cell carcinoma

Carcinoma, Hepatocellular

Carcinoma, Non-Small-Cell Lung

Neoplasms

Medullary thyroid gland carcinoma

Listeriosis

Inherited cancer-predisposing syndrome

Neoplastic Syndromes, Hereditary

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

IPT domain containingMET proto-oncogene, receptor tyrosine kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-01-15.

Open TargetsGene–disease associations from the Open Targets Platform.