MLH1

Gene

mutL homolog 1

HGNCHGNC:7127 EnsemblENSG00000076242 NCBI Gene4292

Locus: gene with protein productLocation: 3p22.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

DNA mismatch repair protein Mlh1P40692

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCOCA2 · HNPCC · FCC2 · HNPCC2 · MLH-1

View full nomenclature history (7)

Previous symbolsCOCA2

Alias symbolsHNPCC, FCC2, HNPCC2, MLH-1

Previous namesmutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2), mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Colorectal Neoplasms, Hereditary Nonpolyposis

Colorectal Neoplasms

Colon carcinoma

Colonic Neoplasms

Endometrial Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

MutL homologsBRCA1-associated genome surveillance complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.