MSH4

Gene

mutS homolog 4

HGNCHGNC:7327 EnsemblENSG00000057468 NCBI Gene4438

Locus: gene with protein productLocation: 1p31.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

View full nomenclature history (2)

Previous namesmutS (E. coli) homolog 4, mutS homolog 4 (E. coli)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic non-acquired premature ovarian failure

Primary Ovarian Insufficiency

46,XX gonadal dysgenesis

Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

MutS homologs

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.