MST1R

Gene

macrophage stimulating 1 receptor

HGNCHGNC:7381 EnsemblENSG00000164078 NCBI Gene4486

Locus: gene with protein productLocation: 3p21.31

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Macrophage-stimulating protein receptorQ04912

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asRON · PTK8 · SEA · CDw136 · CD136

View full nomenclature history (9)

Previous symbolsRON, PTK8, SEA

Alias symbolsCDw136, CD136

Previous namesPTK8 protein tyrosine kinase 8, S13 erythroblastosis (avian) oncogene homolog, S13 avian erythroblastosis oncogene homolog

Alias namesc-met-related tyrosine kinase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Nasopharyngeal Neoplasms

Carcinoma, Non-Small-Cell Lung

Neoplasms

Nasopharyngeal Carcinoma

Inflammatory myofibroblastic tumor

Diabetes Mellitus

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesIPT domain containingMET proto-oncogene, receptor tyrosine kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.