MTOR

Gene

mechanistic target of rapamycin kinase

HGNCHGNC:3942 EnsemblENSG00000198793 NCBI Gene2475

Locus: gene with protein productLocation: 1p36.22

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Serine/threonine-protein kinase mTORP42345

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFRAP · FRAP2 · FRAP1 · RAFT1 · RAPT1 · FLJ44809

View full nomenclature history (17)

Previous symbolsFRAP, FRAP2, FRAP1

Alias symbolsRAFT1, RAPT1, FLJ44809

Previous namesFK506 binding protein 12-rapamycin associated protein 1, mechanistic target of rapamycin (serine/threonine kinase), mechanistic target of rapamycin

Alias namesFK506 binding protein 12-rapamycin associated protein 2, rapamycin target protein, FKBP12-rapamycin complex-associated protein 1, FKBP-rapamycin associated protein, rapamycin associated protein FRAP2, dJ576K7.1 (FK506 binding protein 12-rapamycin associated protein 1), rapamycin and FKBP12 target 1, mammalian target of rapamycin

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes

Neurodegenerative Diseases

Carcinoma, Renal Cell

Genetic Diseases, Inborn

Alzheimer's Disease

Parkinson's Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

MTOR complex 1MTOR complex 2Armadillo like helical domain containingPhosphatidylinositol 3-kinase-related kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-02-11.

Open TargetsGene–disease associations from the Open Targets Platform.