MYLK

Gene

myosin light chain kinase

HGNCHGNC:7590 EnsemblENSG00000065534 NCBI Gene4638

Locus: gene with protein productLocation: 3q21.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Myosin light chain kinase, smooth muscleQ15746

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMLCK · smMLCK · MYLK1 · MLCK1 · KRP · Telokin · MLCK108 · MLCK210 · MYLK-L

View full nomenclature history (12)

Alias symbolsMLCK, smMLCK, MYLK1, MLCK1, KRP, Telokin, MLCK108, MLCK210, MYLK-L

Previous namesmyosin, light polypeptide kinase

Alias namessmooth muscle myosin light chain kinase, kinase related protein

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Lymphohistiocytosis, Hemophagocytic

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Fibronectin type III domain containingI-set domain containingMyosin light chain kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.