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NKX2-1

Gene

NK2 homeobox 1

HGNCHGNC:11825EnsemblENSG00000136352NCBI Gene7080
Locus: gene with protein productLocation: 14q13.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNKX2A · BCH · TITF1 · TTF-1 · TTF1
View full nomenclature history (7)
Previous symbolsNKX2A, BCH, TITF1
Alias symbolsTTF-1, TTF1
Previous namesbenign chorea, thyroid transcription factor 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn
Neurodegenerative Diseases
Adenocarcinoma, Follicular
Carcinoma, Non-Small-Cell Lung

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

NKL subclass homeoboxes and pseudogenes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.