NLRP3

Gene

NLR family pyrin domain containing 3

HGNCHGNC:16400 EnsemblENSG00000162711 NCBI Gene114548

Locus: gene with protein productLocation: 1q44

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC1orf7 · CIAS1 · DFNA34 · AGTAVPRL · AII · AVP · FCAS · FCU · NALP3 · PYPAF1 · MWS · CLR1.1

View full nomenclature history (16)

Previous symbolsC1orf7, CIAS1, DFNA34

Alias symbolsAGTAVPRL, AII, AVP, FCAS, FCU, NALP3, PYPAF1, MWS, CLR1.1

Previous namescold autoinflammatory syndrome 1, deafness, autosomal dominant 34

Alias namesnucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3, Cryopyrin

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Muckle-Wells syndrome

Cryopyrin-associated Periodic Syndromes

Severe Acute Respiratory Syndrome

COVID-19

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

NLR familyPyrin domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.