NLRP4

Gene

NLR family pyrin domain containing 4

HGNCHGNC:22943 EnsemblENSG00000160505 NCBI Gene147945

Locus: gene with protein productLocation: 19q13.43

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNALP4 · PYPAF4 · FLJ32126 · PAN2 · RNH2 · CLR19.5 · CT58

View full nomenclature history (10)

Previous symbolsNALP4

Alias symbolsPYPAF4, FLJ32126, PAN2, RNH2, CLR19.5, CT58

Previous namesNACHT, leucine rich repeat and PYD containing 4

Alias namesnucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4, cancer/testis antigen 58

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Macular Degeneration

Diabetic Ketoacidosis

Neoplasms

Pancreatic Neoplasms

Down Syndrome

Carcinoma, Non-Small-Cell Lung

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

NLR familyPyrin domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.