NTRK1

Gene

neurotrophic receptor tyrosine kinase 1

HGNCHGNC:8031 EnsemblENSG00000198400 NCBI Gene4914

Locus: gene with protein productLocation: 1q23.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

High affinity nerve growth factor receptorP04629

Protein · therapeutic target

Clinically validated target · 7 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTRK · TRKA · MTC

View full nomenclature history (6)

Alias symbolsTRK, TRKA, MTC

Previous namesneurotrophic tyrosine kinase, receptor, type 1

Alias nameshigh affinity nerve growth factor receptor, tropomyosin receptor kinase A

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hereditary sensory and autonomic neuropathy type 4

Carcinoma, Non-Small-Cell Lung

Neoplasms

Colorectal Neoplasms

Familial medullary thyroid carcinoma

Genetic Diseases, Inborn

Neurodegenerative Diseases

Colorectal adenocarcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Immunoglobulin like domain containingNeurotrophic receptor tyrosine kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-05-02.

Open TargetsGene–disease associations from the Open Targets Platform.