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OCLN

Gene

occludin

HGNCHGNC:8104EnsemblENSG00000197822NCBI Gene100506658
Locus: gene with protein productLocation: 5q13.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

OccludinQ16625

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPPP1R115
View full nomenclature history (3)
Alias symbolsPPP1R115
Alias namestight junction protein occludin TM4 minus, phosphatase 1, regulatory subunit 115

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hypertension
Neurodegenerative Diseases
Nephrolithiasis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Protein phosphatase 1 regulatory subunitsTetraspan junctional complex superfamilyMARVEL domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.