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OPTN

Gene

optineurin

HGNCHGNC:17142EnsemblENSG00000123240NCBI Gene10133
Locus: gene with protein productLocation: 10p13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGLC1E · FIP2 · HYPL · FIP-2 · TFIIIA-INTP · NRP · HIP7
View full nomenclature history (8)
Previous symbolsGLC1E
Alias symbolsFIP2, HYPL, FIP-2, TFIIIA-INTP, NRP, HIP7
Previous namesglaucoma 1, open angle, E (adult-onset)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Glaucoma, Open-Angle
Amyotrophic Lateral Sclerosis
Genetic Diseases, Inborn
Motor Neuron Disease
bone Paget's disease
Sarcoidosis
Frontotemporal Dementia
Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Zinc fingers C2HC NEMO-type

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.