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P4HTM

Gene

prolyl 4-hydroxylase, transmembrane

HGNCHGNC:28858EnsemblENSG00000178467NCBI Gene54681
Locus: gene with protein productLocation: 3p21.31

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Transmembrane prolyl 4-hydroxylaseQ9NXG6

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

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Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asP4H-TM · PHD4 · PH4 · HIFPH4 · FLJ20262 · EGLN4 · PH-4
View full nomenclature history (10)
Alias symbolsP4H-TM, PHD4, PH4, HIFPH4, FLJ20262, EGLN4, PH-4
Previous namesprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Alias namesProlyl hydroxlase domain-containing 4, hypoxia inducible factor prolyl 4 hydroxylase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Anemia
Kidney Failure, Chronic

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Iron (II) and 2-oxoglutarate dependent oxygenases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.