PAF1

Gene

PAF1 component of Paf1/RNA polymerase II complex

HGNCHGNC:25459 EnsemblENSG00000006712 NCBI Gene54623

Locus: gene with protein productLocation: 19q13.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPD2 · F23149_1 · FLJ11123

View full nomenclature history (5)

Alias symbolsPD2, F23149_1, FLJ11123

Previous namesPAF1 homolog, Paf1/RNA polymerase II complex component, Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Parkinson's Disease

Alzheimer's Disease

Lysosomal Storage Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Paf1/RNA polymerase II complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-07-02.

Open TargetsGene–disease associations from the Open Targets Platform.