PDE3A

Gene

phosphodiesterase 3A

HGNCHGNC:8778 EnsemblENSG00000172572 NCBI Gene5139

Locus: gene with protein productLocation: 12p12.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3AQ14432

Protein · therapeutic target

Clinically validated target · 17 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCGI-PDE

View full nomenclature history (3)

Alias symbolsCGI-PDE

Previous namesphosphodiesterase 3A, cGMP-inhibited

Alias namescGMP-inhibited 3',5'-cyclic phosphodiesterase A

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Coronary Artery Disease

Cardiovascular Diseases

Stroke

Asthma

Heart Failure

Pulmonary Disease, Chronic Obstructive

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Phosphodiesterases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.