PDE4B

Gene

phosphodiesterase 4B

HGNCHGNC:8781 EnsemblENSG00000184588 NCBI Gene5142

Locus: gene with protein productLocation: 1p31.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

3',5'-cyclic-AMP phosphodiesterase 4BQ07343

Protein · therapeutic target

Clinically validated target · 15 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDPDE4

View full nomenclature history (6)

Previous symbolsDPDE4

Previous namesphosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4), phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila), phosphodiesterase 4B, cAMP-specific

Alias namescAMP-specific 3',5'-cyclic phosphodiesterase 4B, phosphodiesterase E4 dunce homolog (Drosophila)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Asthma

Pulmonary Disease, Chronic Obstructive

Coronary Artery Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Phosphodiesterases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.