PF4

Gene

platelet factor 4

HGNCHGNC:8861 EnsemblENSG00000163737 NCBI Gene5196

Locus: gene with protein productLocation: 4q13.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Platelet factor 4P02776

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSCYB4 · CXCL4

View full nomenclature history (3)

Alias symbolsSCYB4, CXCL4

Alias nameschemokine (C-X-C motif) ligand 4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Scleroderma, Systemic

Neoplasms

COVID-19

Acquired polycythemia vera

Colorectal Neoplasms

Arthritis, Rheumatoid

Carcinoma, Hepatocellular

Dengue

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.