PIK3CA

Gene

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNCHGNC:8975 EnsemblENSG00000121879 NCBI Gene5290

Locus: gene with protein productLocation: 3q26.32

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformP42336

Protein · therapeutic target

Clinically validated target · 4 approved medicines against this target

Member of “Class Ia Phosphatidylinositol 3-Kinase” · 1 related family paper (context, not papers about this gene)

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPI3K

View full nomenclature history (3)

Alias symbolsPI3K

Previous namesphosphoinositide-3-kinase, catalytic, alpha polypeptide, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Megalencephaly-capillary malformation-polymicrogyria syndrome

CLOVE syndrome

CLOVES syndrome

PIK3CA-related overgrowth spectrum

Breast adenocarcinoma

CLAPO syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Phosphatidylinositol 3-kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.