PLAT

Gene

plasminogen activator, tissue type

HGNCHGNC:9051 EnsemblENSG00000104368 NCBI Gene5327

Locus: gene with protein productLocation: 8p11.21

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tissue-type plasminogen activatorP00750

Protein · therapeutic target

Clinically validated target · 8 approved medicines against this target

Member of “Serine Proteases” · 1 related family paper (context, not papers about this gene)

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

View full nomenclature history (1)

Previous namesplasminogen activator, tissue

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Pulmonary Embolism

Myocardial Infarction

Stroke

Heart Failure

ST Elevation Myocardial Infarction

Ischemic Stroke

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Serine proteasesKringle domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-07-06.

Open TargetsGene–disease associations from the Open Targets Platform.