PLCE1

Gene

phospholipase C epsilon 1

HGNCHGNC:17175 EnsemblENSG00000138193 NCBI Gene51196

Locus: gene with protein productLocation: 10q23.33

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKIAA1516 · PLCE · NPHS3

View full nomenclature history (6)

Alias symbolsKIAA1516, PLCE, NPHS3

Previous namesphospholipase C, epsilon 1

Alias namesnephrosis type 3, phosphoinositide phospholipase C

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Nephrotic Syndrome

Hypertension

Essential Hypertension

Hypertension, Pregnancy-Induced

Aortic Aneurysm

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

PhospholipasesC2 domain containing phospholipases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.