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Disease

Aortic Aneurysm

Late-stage therapeutic developmentEmerging research
MeSHAortic Aneurysm
1
Publications
18
Clinical trials
12
Associated genes
3
Related proteins
2019
Latest publication
Current focus
Lysine 6-oxidase biologyOsteopontin biologyTherapeutic development
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q2 2028.
Upcoming Milestones
Clinical Milestones3View
Results expected 2
Recently completed 1
Activity timeline3

Clinical trials

17 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
18
All trials
6
Active
14
Late-stage
6
Completed
Late-stage studies

Randomized Controlled Clinical Trial (RCT) of the Nectero EAST System for Small to Mid-Sized Abdominal Aortic Aneurysms (AAA) StaBiLization: Evaluation of Efficacy.

Phase 2/3 · Recruiting · Nectero Medical, Inc.

Improved Recovery by Iron Following Surgery With Blood Loss, a Double-blind Multi-centre Randomized Controlled Phase III Drug Trial (the IRIS-trial)

Phase 3 · Recruiting · Jon Unosson

Effect of a Perioperative Opioid Free Anesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response in Elective Open Abdominal Aortic Aneurysm Repair: A Prospective Randomized Study

Phase 4 · Recruiting · University of Crete

Comparison of Intravenous Anesthetics and Volatile Anesthetics on Postoperative Cognitive Dysfunction of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.

Phase 4 · Completed · Tao Zhang

Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial)

Phase 4 · Completed · Yonsei University

The Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms

Phase 3 · Completed · Saskatchewan Health Authority - Regina Area
Recruiting

Randomized Controlled Clinical Trial (RCT) of the Nectero EAST System for Small to Mid-Sized Abdominal Aortic Aneurysms (AAA) StaBiLization: Evaluation of Efficacy.

Phase 2/3 · Recruiting · Nectero Medical, Inc.

Improved Recovery by Iron Following Surgery With Blood Loss, a Double-blind Multi-centre Randomized Controlled Phase III Drug Trial (the IRIS-trial)

Phase 3 · Recruiting · Jon Unosson

Effect of a Perioperative Opioid Free Anesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response in Elective Open Abdominal Aortic Aneurysm Repair: A Prospective Randomized Study

Phase 4 · Recruiting · University of Crete

Hemodynamic Effects Of Aldosterone Receptor Blockade In Degenerative Thoracic Aortic Aneurysm: A Pilot Randomized Controlled Trial (HEART: Pilot RCT)

Phase 1/2 · Recruiting · Mayo Clinic

LIMItIng AAA With meTformin (LIMIT) Trial

Phase 2 · Recruiting · Stanford University

Baystate Health Physician Sponsored - Investigational Device Exception: Physician Modified Endovascular Grafts for the Treatment of Elective, Symptomatic or Ruptured Juxtarenal Aortic Aneurysms

N/A · Recruiting · Baystate Medical Center
Recently completed

The Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms

Phase 3 · Completed · Saskatchewan Health Authority - Regina Area

Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms

Phase 4 · Completed · Palo Alto Veterans Institute for Research

Comparison of Intravenous Anesthetics and Volatile Anesthetics on Postoperative Cognitive Dysfunction of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.

Phase 4 · Completed · Tao Zhang

Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial)

Phase 4 · Completed · Yonsei University

Effects of OctaplasLG® on Endothelial Integrity in Patients Undergoing Emergency Surgery for Thoracic Aortic Dissections - a Randomized, Controlled, Single-blinded Investigator-initiated Pilot Trial

Phase 4 · Completed · Rigshospitalet, Denmark

Curcumin to Prevent Perioperative Complications After Elective Abdominal Aortic Aneurysm Repair: a Randomized Controlled Trial

Phase 2/3 · Completed · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

A population-based study of cardiovascular disease mortality risk in US cancer patients.

European heart journal · 2019 · 689 cites
Recent publications

A population-based study of cardiovascular disease mortality risk in US cancer patients.

European heart journal · 2019 · 689 cites
Leading journals1
  • European heart journal1
Leading researchers8
  • Bluethmann SM1
  • Deng L1
  • Jiang C1
  • Kelly SP1
  • Sturgeon KM1
  • Trifiletti DM1
  • Zaorsky NG1
  • Zhou S1
Affiliations (unnormalised)6
  • Icahn School of Medicine at Mount Sinai1
  • Jacobi Medical Center1
  • Mayo Clinic1
  • National Institutes of Health1
  • Penn State Cancer Institute1
  • Penn State College of Medicine1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

FBN10.73ADAMTS80.47EFEMP20.47LOX0.47ARIH10.45NOC3L0.45PCSK10.44DAB2IP0.43LOXL10.42PRDM60.42PLCE10.41GDF70.41

Disease biology

3 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Protein-lysine 6-oxidasevia LOX0.47Osteopontinvia SPP10.36Oncostatin-Mvia OSM0.10

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

An abnormal balloon- or sac-like dilatation in the wall of AORTA.

Identifiers
MeSHAortic Aneurysm
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.