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PCSK1

Gene

proprotein convertase subtilisin/kexin type 1

HGNCHGNC:8743EnsemblENSG00000175426NCBI Gene5122
Locus: gene with protein productLocation: 5q15

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNEC1 · PC1 · PC3 · SPC3 · PC1/3
View full nomenclature history (9)
Previous symbolsNEC1
Alias symbolsPC1, PC3, SPC3, PC1/3
Previous namesneuroendocrine convertase 1
Alias namesprohormone convertase 3, prohormone convertase 1, proprotein convertase 1/3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Obesity disorder
Diabetes, Gestational
Osteoarthritis, Knee
Aneurysm
Aortic Aneurysm
Smoking initiation
Obesity due to melanocortin 4 receptor deficiency
Osteoarthritis, Hip

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Proprotein convertase subtilisin/kexin family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.