Back to discover
Disease

Aneurysm

Late-stage therapeutic developmentEmerging research
MeSHAneurysm
1
Publications
20
Clinical trials
12
Associated genes
3
Related proteins
2021
Latest publication
Current focus
Osteopontin biologyStearoyl-coa desaturase biologyTherapeutic developmentInflammation & immunity
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 2 clinical trials expected to report results, the earliest in Q2 2027.
Upcoming Milestones
Clinical Milestones7View
Results expected 2
Recently completed 5
Activity timeline7

Therapeutic landscape

Therapies with a regulatory footing for this condition, alongside the wider set of agents co-studied with it in the literature.

Approved & established therapies
Everolimusapproved

Approval — Renal angiomyolipoma associated with tuberous sclerosis complex (TSC) Votubia is indicate… (2011)

Clinical trials

18 sponsors · 0 new · 2 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
20
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

Randomized Controlled Clinical Trial (RCT) of the Nectero EAST System for Small to Mid-Sized Abdominal Aortic Aneurysms (AAA) StaBiLization: Evaluation of Efficacy.

Phase 2/3 · Recruiting · Nectero Medical, Inc.

US IDE Study of the Contour NEurovasCular System™ for IntraCranial Aneurysm Repair

Phase 4 · Active, not recruiting · Cerus Endovascular, Inc.

Prospective, Post-registration, Interventional, Randomized, in Parallel Groups, Multicenter Eurasian Clinical Study of DERIVO®/DERIVO® Mini Aneurysm Embolization Device, Europe-Asia

Phase 4 · Recruiting · Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health

Improved Recovery by Iron Following Surgery With Blood Loss, a Double-blind Multi-centre Randomized Controlled Phase III Drug Trial (the IRIS-trial)

Phase 3 · Recruiting · Jon Unosson

Effectiveness and Safety of Early Lumbar Drainage Plus Intrathecal Urokinase Injection in the Treatment of Severe Aneurysmal Subarachnoid Hemorrhage (LD-ITUK): a Multicentral Randomized Control Trial

Phase 4 · Recruiting · Second Affiliated Hospital of Nanchang University

Effect of a Perioperative Opioid Free Anesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response in Elective Open Abdominal Aortic Aneurysm Repair: A Prospective Randomized Study

Phase 4 · Recruiting · University of Crete
Recruiting

Randomized Controlled Clinical Trial (RCT) of the Nectero EAST System for Small to Mid-Sized Abdominal Aortic Aneurysms (AAA) StaBiLization: Evaluation of Efficacy.

Phase 2/3 · Recruiting · Nectero Medical, Inc.

Prospective, Post-registration, Interventional, Randomized, in Parallel Groups, Multicenter Eurasian Clinical Study of DERIVO®/DERIVO® Mini Aneurysm Embolization Device, Europe-Asia

Phase 4 · Recruiting · Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health

Improved Recovery by Iron Following Surgery With Blood Loss, a Double-blind Multi-centre Randomized Controlled Phase III Drug Trial (the IRIS-trial)

Phase 3 · Recruiting · Jon Unosson

Effectiveness and Safety of Early Lumbar Drainage Plus Intrathecal Urokinase Injection in the Treatment of Severe Aneurysmal Subarachnoid Hemorrhage (LD-ITUK): a Multicentral Randomized Control Trial

Phase 4 · Recruiting · Second Affiliated Hospital of Nanchang University

Effect of a Perioperative Opioid Free Anesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response in Elective Open Abdominal Aortic Aneurysm Repair: A Prospective Randomized Study

Phase 4 · Recruiting · University of Crete
Recently completed

Optimal Duration of Dual Antiplatelet Therapy After Stent-assisted Coiling of Unruptured Intracranial Aneurysms: A Prospective Randomized Multicenter Trial

Phase 4 · Completed · Seoul National University Bundang Hospital

Prophylactic Administration of Tirofiban for Preventing Thromboembolic Events in Stent-assisted Coiling and Flow Diversion Treatments of Unruptured Intracranial Aneurysms

Phase 2/3 · Completed · Beijing Tiantan Hospital

Seizure Prophylaxis in Aneurysm Repair

Phase 4 · Completed · University of Michigan

Randomized, Double-blind, Placebo-controlled Single-centre Clinical Trial Evaluating Efficacy and Safety of Intraoperative and Postoperative Continuous Lidocaine Infusion in High Cardiac Risk Vascular Surgery

Phase 4 · Completed · Łukasz Krzych

Comparison of Dual-Antiplatelet and Triple-Antiplatelet Preparation Using P2Y12 Assay in Patients With High On-Treatment Platelet Reactivity Undergoing Stent-Assisted Coil Embolization for An Unruptured Intracranial Aneurysm

Phase 4 · Completed · Seoul National University Hospital

Ticagrelor Versus Clopidogrel for Platelet Inhibition in Patients Undergoing Neurovascular Stenting for Intracranial Aneurysm

Phase 3 · Completed · Fondation Ophtalmologique Adolphe de Rothschild

Regulatory timeline

Drug regulatory events matched to this condition by indication — EMA.

First approvals
2011emaApproval — Everolimus· Renal angiomyolipoma associated with tuberous sclerosis complex (TSC) Votubia is indicated for the treatment of adult patients with renal angiomyolipoma associated with tuberous sclerosis complex (TSC) who are at risk of complications (based on factors such as tumour size or presence of aneurysm, or presence of multiple or bilateral tumours) but who do not require immediate surgery. The evidence is based on analysis of change in sum of angiomyolipoma volume. Subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (TSC) Votubia is indicated for the treatment of patients with subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (TSC) who require therapeutic intervention but are not amenable to surgery. The evidence is based on analysis of change in SEGA volume. Further clinical benefit, such as improvement in disease?related symptoms, has not been demonstrated. source ↗

European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Recent publications

Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease.

Circulation research · 2021 · 459 cites
Major themes1
  • Interleukin-6 Inhibitors1
Leading journals1
  • Circulation research1
Leading researchers2
  • Rane M1
  • Ridker PM1
Affiliations (unnormalised)1
  • Center for Cardiovascular Disease Prevention1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

PCSK10.44NOX40.44DAB2IP0.43NOC3L0.40CHRNA30.40ADAMTS80.40CHRNB40.39MRC20.39LOXL10.38CTAGE10.37PRDM60.37SPP10.36

Disease biology

3 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

NADPH oxidase 4via NOX40.44Osteopontinvia SPP10.36Stearoyl-CoA desaturasevia SCD0.27

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.

Identifiers
MeSHAneurysm
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.