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SPP1

Gene

secreted phosphoprotein 1

HGNCHGNC:11255EnsemblENSG00000118785NCBI Gene6696
Locus: gene with protein productLocation: 4q22.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

OsteopontinP10451

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asBNSP · OPN · BSPI · ETA-1 · lnc-PKD2-2-3
View full nomenclature history (8)
Previous symbolsBNSP, OPN
Alias symbolsBSPI, ETA-1, lnc-PKD2-2-3
Previous namesosteopontin, bone sialoprotein I
Alias namesearly T-lymphocyte activation 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Osteoporosis
Bone Diseases
Gout
Aneurysm
Aortic Aneurysm
Placental abruption
Mouth Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Receptor ligandsSIBLING family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.