POLA1

Gene

DNA polymerase alpha 1, catalytic subunit

HGNCHGNC:9173 EnsemblENSG00000101868 NCBI Gene5422

Locus: gene with protein productLocation: Xp22.11-p21.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

DNA polymerase alpha catalytic subunitP09884

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPOLA · NSX · p180

View full nomenclature history (6)

Previous symbolsPOLA, NSX

Alias symbolsp180

Previous namespolymerase (DNA directed), alpha, N syndrome (mental retardation, malformations, chromosome breakage), polymerase (DNA) alpha 1, catalytic subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Carcinoma, Non-Small-Cell Lung

Leukemia, Lymphocytic, Chronic, B-Cell

Leukemia, Myeloid, Acute

Ovarian carcinoma

Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

DNA polymerases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.