POLE

Gene

DNA polymerase epsilon, catalytic subunit

HGNCHGNC:9177 EnsemblENSG00000177084 NCBI Gene5426

Locus: gene with protein productLocation: 12q24.33

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

DNA polymerase epsilon catalytic subunit AQ07864

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPOLE1

View full nomenclature history (4)

Alias symbolsPOLE1

Previous namespolymerase (DNA directed), epsilon, polymerase (DNA) epsilon, catalytic subunit

Alias namesDNA polymerase epsilon catalytic subunit A

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Non-Small-Cell Lung

Leukemia, Lymphocytic, Chronic, B-Cell

Leukemia, Myeloid, Acute

Exocrine pancreatic carcinoma

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Colorectal Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

DNA polymerases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.