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POLR2A

Gene

RNA polymerase II subunit A

HGNCHGNC:9187EnsemblENSG00000181222NCBI Gene5430
Locus: gene with protein productLocation: 17p13.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

DNA-directed RNA polymerase II subunit RPB1P24928

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPOLR2 · POLRA · RPB1
View full nomenclature history (6)
Previous symbolsPOLR2
Alias symbolsPOLRA, RPB1
Previous namespolymerase (RNA) II (DNA directed) polypeptide A, 220kDa
Alias namesDNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit, RNA polymerase II subunit B1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

HIV Infections
Genetic Diseases, Inborn
Influenza, Human
Autistic Disorder
Dengue

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

RNA polymerase subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2021-05-26.
Open TargetsGene–disease associations from the Open Targets Platform.