POU4F3

Gene

POU class 4 homeobox 3

HGNCHGNC:9220 EnsemblENSG00000091010 NCBI Gene5459

Locus: gene with protein productLocation: 5q32

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDFNA15 · DFNA52 · DFNA42 · BRN3C

View full nomenclature history (7)

Previous symbolsDFNA15, DFNA52, DFNA42

Alias symbolsBRN3C

Previous namesPOU domain class 4, transcription factor 3, deafness, autosomal dominant 52, deafness, autosomal dominant 42

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Deafness

Non-syndromic genetic deafness

Nonsyndromic genetic hearing loss

Hearing loss, autosomal recessive

Wounds and Injuries

Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

POU class homeoboxes and pseudogenes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.