POU5F1

Gene

POU class 5 homeobox 1

HGNCHGNC:9221 EnsemblENSG00000204531 NCBI Gene5460

Locus: gene with protein productLocation: 6p21.33

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asOTF3 · OCT3 · Oct4 · MGC22487 · OCT-4 · Oct3/4

View full nomenclature history (7)

Previous symbolsOTF3

Alias symbolsOCT3, Oct4, MGC22487, OCT-4, Oct3/4

Previous namesPOU domain class 5, transcription factor 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Gastric carcinoma

Lung carcinoma

Breast Neoplasms

Carcinoma, Non-Small-Cell Lung

Squamous Cell Carcinoma of Head and Neck

Urinary bladder carcinoma

Leukemia, Myeloid, Acute

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

POU class homeoboxes and pseudogenes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.