PREX1

Gene

phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1

HGNCHGNC:32594 EnsemblENSG00000124126 NCBI Gene57580

Locus: gene with protein productLocation: 20q13.13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKIAA1415 · P-REX1

View full nomenclature history (4)

Alias symbolsKIAA1415, P-REX1

Previous namesphosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

Alias namesPIP3 dependent Rac exchange factor 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hypertension

Hypothyroidism

Essential Hypertension

Coronary Artery Disease

Colonic Polyps

Pre-Eclampsia

Hypertension, Pregnancy-Induced

Cardiovascular Diseases

Intelligence

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Pleckstrin homology domain containingDbl family Rho GEFsPDZ domain containingDEP domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.