Back to discover

PREX2

Gene

phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2

HGNCHGNC:22950EnsemblENSG00000046889NCBI Gene80243
Locus: gene with protein productLocation: 8q13.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDEPDC2 · DEP.2 · FLJ12987 · P-REX2 · PPP1R129
View full nomenclature history (8)
Previous symbolsDEPDC2
Alias symbolsDEP.2, FLJ12987, P-REX2, PPP1R129
Previous namesDEP domain containing 2, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Alias namesprotein phosphatase 1, regulatory subunit 129

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Lung carcinoma
Cutaneous melanoma
Carcinoma, Pancreatic Ductal
Carcinoma of liver and intrahepatic biliary tract
Carcinoma, Merkel Cell
Lymphoid neoplasm

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Protein phosphatase 1 regulatory subunitsDbl family Rho GEFsPDZ domain containingDEP domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.