Carcinoma, Merkel Cell
Recent clinical, regulatory, research and industry developments relating to this disease.
Merkel Cell Carcinoma: Integrating Epidemiology, Immunology, and Therapeutic Updates.
Non-Melanoma Skin Cancers: Biological and Clinical Features.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 1 clinical trial expected to report results, the earliest in Q1 2029.
Clinical MilestonesViewHide
Therapeutic landscape
Therapies with a regulatory footing for this condition, alongside the wider set of agents co-studied with it in the literature.
Approval — Squamous cell carcinoma of the anal canal (SCAC) Zynyz is indicated in combination with c… (2024)
Approval — Bavencio is indicated as monotherapy for the treatment of adult patients with metastatic… (2017)
Clinical trials
The current development programme across all trial phases.
Regulatory timeline
Drug regulatory events matched to this condition by indication — EMA.
European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes4
- Carcinoma, Merkel Cell1
- Gene Expression Regulation, Neoplastic1
- Immune Checkpoint Inhibitors1
- Skin Neoplasms1
Leading journals2
- American journal of clinical dermatology1
- International journal of molecular sciences1
Leading researchers8
- Becker JC1
- Cavallo F1
- Cazzato G1
- Cives M1
- Filoni E1
- Giudice G1
- Lospalluti L1
- Mannavola F1
Affiliations (unnormalised)6
- Azienda Ospedaliero-Universitaria Policlinico di Bari1
- Department of Biomedical Sciences and Clinical Oncology (DIMO)1
- German Cancer Research Center (DKFZ)1
- Institute of Medical Informatics1
- National Cancer Center1
- University Duisburg-Essen1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Reference
Authoritative identity, definition & identifiers.
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.