CD274

Gene

CD274 molecule

HGNCHGNC:17635 EnsemblENSG00000120217 NCBI Gene29126

Locus: gene with protein productLocation: 9p24.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Programmed cell death 1 ligand 1Q9NZQ7

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPDCD1LG1 · B7-H · B7H1 · PD-L1 · PDL1 · B7-H1

View full nomenclature history (9)

Previous symbolsPDCD1LG1

Alias symbolsB7-H, B7H1, PD-L1, PDL1, B7-H1

Previous namesprogrammed cell death 1 ligand 1, CD274 antigen

Alias namesB7 homolog 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Non-Small-Cell Lung

Carcinoma, Merkel Cell

Small Cell Lung Carcinoma

Carcinoma, Hepatocellular

Squamous Cell Carcinoma of Head and Neck

Esophageal Squamous Cell Carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesReceptor ligandsV-set domain containingC2-set domain containingB7 family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.