PRPF8

Gene

pre-mRNA processing factor 8

HGNCHGNC:17340 EnsemblENSG00000174231 NCBI Gene10594

Locus: gene with protein productLocation: 17p13.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asRP13 · PRPC8 · Prp8 · hPrp8 · SNRNP220

View full nomenclature history (7)

Previous symbolsRP13

Alias symbolsPRPC8, Prp8, hPrp8, SNRNP220

Previous namesPRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae), PRP8 pre-mRNA processing factor 8 homolog (yeast)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Retinitis Pigmentosa

Retinal Diseases

Genetic Diseases, Inborn

Eye Diseases

Complex neurodevelopmental disorder

Dengue

Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

JAMM/MPN+ metallopeptidase familyU5 small nuclear ribonucleoproteinSpliceosomal Bact complexSpliceosomal C complexSpliceosomal P complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.