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PSMC3

Gene

proteasome 26S subunit, ATPase 3

HGNCHGNC:9549EnsemblENSG00000165916NCBI Gene5702
Locus: gene with protein productLocation: 11p11.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

26S proteasome regulatory subunit 6AP17980

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTBP1 · TBP-1 · RPT5
View full nomenclature history (5)
Alias symbolsTBP1, TBP-1, RPT5
Previous namesproteasome (prosome, macropain) 26S subunit, ATPase, 3
Alias namesTat-binding protein-1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodevelopmental Disorders
Multiple Myeloma
Neurodegenerative Diseases
Neoplasms
Genetic Diseases, Inborn
HIV Infections
Microcephaly

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

AAA ATPasesProteasome

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.