Back to discover

PTEN

Gene

phosphatase and tensin homolog

HGNCHGNC:9588EnsemblENSG00000171862NCBI Gene5728
Locus: gene with protein productLocation: 10q23.31

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENP60484

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asBZS · MHAM · MMAC1 · TEP1 · PTEN1
View full nomenclature history (7)
Previous symbolsBZS, MHAM
Alias symbolsMMAC1, TEP1, PTEN1
Alias namesmutated in multiple advanced cancers 1, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Glioma
Melanoma
Squamous Cell Carcinoma of Head and Neck

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

C2 tensin-type domain containingPTEN protein phosphatasesPhosphoinositide phosphatases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-11-09.
Open TargetsGene–disease associations from the Open Targets Platform.